Towards High-Throughput Label Free Detection of Biomolecular Interactions on Glass Substrates
نویسنده
چکیده
My summer research project as an REU student at UC Davis has mainly been an effort to create and motivate methods to achieve high-throughput screening of biomolecules from the National Cancer Institute (NCI) as possible treatments for various types of cancer. The hope of my advisor, Dr. Xiang Dong Zhu, and the rest of his group is to offer a competitive label-free drug screening technique to the market. Our microscopes use ellipsometry in a technique called oblique-incidence reflectivity difference (OI-RD) microscopy to detect biomolecular reactions in situ and in real time without the use of the fluorescent tagging used by all other drug screening companies and laboratories. Such a technique, if high-throughput is achieved, has powerful implications for the future of drug screening.
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